Synthesis and Antibacterial and Immunobiological Activity of Ethyl-1-(4-Aminosulfonylphenyl)-5-Aryl-3-Hydroxy-2-Oxo-3-Pyrroline-4-Carboxylates
| Autor: | O. V. Bobrovskaya, E. É. Sopova, O. N. Gein, I. V. Krylova, S. V. Gein, V. L. Gein, T. F. Odegova |
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| Rok vydání: | 2016 |
| Předmět: |
Pharmacology
chemistry.chemical_classification 010405 organic chemistry Sodium Aryl Pharmacology toxicology chemistry.chemical_element Pyrroline 010402 general chemistry Mass spectrometry 01 natural sciences Aldehyde 0104 chemical sciences chemistry.chemical_compound chemistry Drug Discovery Organic chemistry Spectroscopy |
| Zdroj: | Pharmaceutical Chemistry Journal. 49:677-679 |
| ISSN: | 1573-9031 0091-150X |
| Popis: | A series of ethyl-1-(4-aminosulfonylphenyl)-5-aryl-3-hydroxy-2-oxo-3-pyrroline-4-carboxylates were synthesized via a three-component reaction of sodium diethyloxalylacetate and a mixture of an aromatic aldehyde and 4-aminobenzenesulfonamide. The structures of the compounds were established using IR and PMR spectroscopy and mass spectrometry. The antibacterial and immunobiological activities of the synthesized compounds were studied. |
| Databáze: | OpenAIRE |
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