Clinical Implications of the EGF Receptor/Ligand System for Tumor Progression and Survival in Gastrointestinal Carcinomas: Evidence for New Therapeutic Options
| Autor: | Reinhard Kopp, Elisabeth Rothbauer, Friedrich W. Schildberg, D. G. Pfeiffer, Michael H. Muders, Andreas Pfeiffer, Hans Arnholdt, Maximilian Ruge, Joachim Spranger |
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| Rok vydání: | 2003 |
| Předmět: |
Betacellulin
Pathology medicine.medical_specialty biology business.industry Cancer medicine.disease Intestinal mucosa Amphiregulin Epidermal growth factor Tumor progression biology.protein Medicine Neuregulin Epidermal growth factor receptor business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Molecular Staging of Cancer ISBN: 9783642639456 |
| DOI: | 10.1007/978-3-642-59349-9_10 |
| Popis: | The epidermal growth factor (EGF) receptor and its various ligands (EGF, TGF-α, amphiregulin, heparin-binding (HB)-EGF, heregulin, betacellulin) seem to be involved in the growth regulation of intestinal mucosa and might be related to the development and progression of gastrointestinal tumors. However, few quantitative data investigating the impact of tumor-EGF receptor levels in gastrointestinal carcinomas on tumor stage and prognosis are available. Therefore, EGF receptors were quantitatively determined in colorectal carcinomas in comparison to adjacent normal mucosa by 125I[EGF]-binding studies. EGFR capacity was increased in advanced invasive colorectal carcinomas (Tl/2 vs. T3/4 tumors, p |
| Databáze: | OpenAIRE |
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