Synthesis of a new class of Tc chelating agents: N2S2 monoaminemonoamide (mama) ligands

Autor:	Ananthachari Srinivasan, Linda M. Gustavson, Tripuraneni N. Rao, David S. Jones, Alan R. Fritzberg
Rok vydání:	1991
Předmět:	medicine.drug_class Chemistry Stereochemistry Organic Chemistry Kinetics Carboxamide Biochemistry chemistry.chemical_compound Covalent bond Amide Drug Discovery Bifunctional chelate medicine Chelation Amine gas treating Aliphatic compound
Zdroj:	Tetrahedron Letters. 32:5485-5488
ISSN:	0040-4039
DOI:	10.1016/0040-4039(91)80064-d
Popis:	A novel N2S2-monoamine amide (MAMA) bifunctional chelate was designed and synthesized for labeling of antibodies with Tc-99m. The chelate forms Tc complexes at a range of pH's and shows faster kinetics of complexation than N2S2-diamidedithiol (DADS) ligands. The MAMA chelate contains a carboxyl group for covalent attachment to amino groups on proteins.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::605528f63203c52c4312b18a525841a8 https://doi.org/10.1016/0040-4039(91)80064-d Zobrazit plný text záznamu