Alpha2-and beta2-adrenoceptor downregulation in marathon runners
| Autor: | H M Thiede, Markus Rothschild, Klaus-Detlev Schultz, Andreas Kribben, Armin Distler, E Fritschka, Thomas Philipp |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Sympathetic nervous system Mean arterial pressure Physiology business.industry Alpha (ethology) Adrenergic Endocrinology medicine.anatomical_structure Internal medicine Heart rate Internal Medicine Catecholamine medicine Alpha-2 adrenergic receptor Cardiology and Cardiovascular Medicine Beta (finance) business medicine.drug |
| Zdroj: | Journal of Hypertension. 7:S48-49 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/00004872-198900076-00021 |
| Popis: | The regulation of platelet alpha 2- and lymphocyte beta 2-adrenoceptor densities by alterations in endogenous catecholamines was examined. In order to activate the sympathetic nervous system eight trained male normotensive subjects carried out a marathon run. Adrenoceptor densities and plasma catecholamine concentrations were measured before and immediately after the run. Platelet alpha 2-adrenoceptor density and lymphocyte beta-adrenoceptor density decreased after the run (P less than 0.05), whereas both plasma noradrenaline and adrenaline concentrations increased (P less than 0.01). Mean arterial pressure decreased (P less than 0.05), and the heart rate increased (P less than 0.001). The data suggest that increases in endogenous catecholamine concentrations cause downregulation of both alpha- and beta-adrenoceptor densities on human blood cells. |
| Databáze: | OpenAIRE |
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