Prevalence of A2 and A2B Subgroups and Anti-A1 Antibody in Blood Donors in Jazan, Saudi Arabia
| Autor: | Muhammad Saboor, Saleh Mohammed Abdullah, Aymen M. Madkhali, Amr J Halawani, Hassan A Hamali, Abdullah A Mobarki, Amtuz Zehra |
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| Rok vydání: | 2020 |
| Předmět: |
Blood type
education.field_of_study biology business.industry Population General Medicine 030204 cardiovascular system & hematology Phenotype 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis ABO blood group system Immunology biology.protein Medicine Antibody business education |
| Zdroj: | International Journal of General Medicine. 13:787-790 |
| ISSN: | 1178-7074 |
| Popis: | Purpose A2 and A2B are rare phenotypes of the ABO blood group system. Some individuals with A2 and A2B may have anti-A1 antibodies that may be clinically significant or insignificant. The aim of this study was to determine the frequency of A2, A2B phenotypes and anti-A1 antibodies in blood donors in Jazan, Saudi Arabia. This study also evaluated the reactivity potential of anti-A1 antibodies. Materials and methods Blood samples collected from 446 blood donors were typed for ABO (cell and serum grouping) and Rh D. Individuals with blood group A and AB were further subtyped by testing with anti-A1 lectin. In addition to the serum grouping using A1 red cells, A2 and A2B individuals were screened for the presence of anti-A1 in their sera against A1 red cells at 4°C, 22°C and 37°C to determine the thermal amplitude of the reacting anti-A1 antibody (if present). Results Among A and AB, A1 was the commonest phenotype (20.2%, n=90 out of 446) while A1B was found to be 1.8% (n=8) among AB phenotype. A2 and A2B were found to be 2.2% (n=10) and 0.9% (n=4), respectively. Only one individual with A2B blood type showed cold reactive anti-A1 antibody, the strength of which was 32. Conclusion A2 and A2B were the rarest among ABO phenotypes in the studied population. Although rare, anti-A1 antibody is not so uncommon. Care shall be taken during routine ABO grouping especially in cases of mix-field or weak positive reactions in A and AB phenotypes. |
| Databáze: | OpenAIRE |
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