The Effects of Topical Corticosteroids and Plasmin Inhibitors on Refractive Outcome, Haze, and Visual Performance after Photorefractive Keratectomy
| Autor: | Malcolm G. Kerr-Muir, Melanie C. Corbett, David P.S. O'Brart, Chris P. Lohmann, John Marshall, William S.T. Pollock, Gregory Klonos |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Corneal Haze Visual acuity Antifibrinolytic genetic structures medicine.drug_class business.industry medicine.medical_treatment eye diseases Photorefractive keratectomy Ophthalmology medicine.anatomical_structure Cornea medicine Corticosteroid Aprotinin sense organs medicine.symptom business Fluorometholone medicine.drug |
| Zdroj: | Ophthalmology. 101:1565-1574 |
| ISSN: | 0161-6420 |
| Popis: | Background: This study of 86 patients with 12 months of follow-up was designed to determine whether topical corticosteroids or plasmin inhibitors have an effect on the outcome of photorefractive keratectomy. Methods: Patients were allocated randomly to either steroid (0.1% fluorometholone for 6 months), plasmin-inhibitor (aprotinin 40 IU/ml for 3 weeks), or control (no treatment) groups and underwent either −3.00- or −6.00-diopter (D) corrections. Results: With −3.00-D corrections, the mean refractive change was significantly greater at 3 and 6 months ( P P P Conclusions: Corticosteroids can maintain a hyperopic shift during their administration, but this effect is reversed on cessation of treatment. Objective tests have shown that steroids have no effect on corneal haze or visual performance after PRK. There is no justification for routinely submitting all patients to long-term steroid regimens and their associated side effects. Treatment with aprotinin produced no beneficial effect on refractive outcome, and haze was greater in the -6.00-D procedures. The concept of modulating the plasminogen activator/plasmin system to regulate wound healing after PRK is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|