L-Citrulline Supplementation Enhances Reproductive Functions of Lead Acetate Induced Testicular Toxicity in Male Sprague Dawley Rats

Autor: D V Dapper, Beatrice Olatundun Oluwatayo, E B Umoren, O. N. Ilochi, T. A. Kolawole
Rok vydání: 2020
Předmět:
Zdroj: Journal of Advances in Medical and Pharmaceutical Sciences. :22-35
ISSN: 2394-1111
DOI: 10.9734/jamps/2020/v22i1230208
Popis: Introduction: Lead (Pb) is a transition metal and a known male reproductive toxicant that induces its effects mainly through oxidative stress. This study investigated the effects of L-Citrulline (Cit) supplement on reproductive functions and antioxidant activities in Lead acetate treated male rats. Materials and Methods: Twenty male rats (180-200 g) were grouped into four and treated as follows; Group 1 (Control), given distilled water, Group 2 was given Pb acetate (2.25mg/kg), Group 3 was co-treated with Pb acetate (2.25mg/kg) and Cit (900mg/kg) and Group 4 was given Cit (900mg/kg) only. All administrations were done orally for thirty days. Caudal sperm, serum hormone levels and testicular antioxidant activities and Nitric oxide levels were evaluated at the end administrations. Results: Results showed decrease (p
Databáze: OpenAIRE