Effects of NSAIDs on cryoprobe-induced gastric ulcer healing in rats
| Autor: | Ingvar Bjarnason, G Sigthorsson, R H Palmer, C Caldwell, J A Tibble |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Ulcer healing
medicine.medical_specialty Hepatology biology business.industry Stomach Gastroenterology Prostaglandin digestive system diseases Nabumetone chemistry.chemical_compound medicine.anatomical_structure chemistry Indometacin Enzyme inhibitor Internal medicine Toxicity Celecoxib biology.protein Medicine Pharmacology (medical) business medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 15:2001-2008 |
| ISSN: | 0269-2813 |
| DOI: | 10.1046/j.1365-2036.2001.01126.x |
| Popis: | Background: Failure of ulcer healing may be critically important to the development of serious gastrointestinal complications in patients on long-term NSAIDs. Aim: To determine the effect of indometacin, celecoxib, a cyclooxygenase-2-specific inhibitor, and nabumetone, a pro-drug, on ulcer healing rates in the rat. Methods: Gastric ulcers were induced using a cryoprobe. An NSAID or a vehicle control was administered to groups of eight rats for 3 or 6 days (2 mg/kg indometacin, 9 mg/kg celecoxib or 40 mg/kg nabumetone). The ulcer area was measured and epithelial proliferation at the ulcer margins was measured histochemically. The effect of the drugs on intestinal prostaglandin levels was also assessed. Results: The mean ulcer sizes in the four groups on day 3 were comparable. On day 6, control animals and those receiving nabumetone showed significant ulcer healing (P |
| Databáze: | OpenAIRE |
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