| Popis: |
Stability in neutral aqueous solutions of a series of nitrosourea derivatives of diamino acids was determined. Structure-activity relationships show that N 3 -bisubstitution increased the stability of these compounds. Moreover, in N 3 -monosubstituted and N 3 -bisubstituted compounds, stability is : N 1 -Methyl > N 1 -Allyl > N 1 -2-Chloroethyl > N 1 -Propargyl. Stability in neutral aqueous solutions of a series of nitrosourea derivatives of diamino acids was determined. Structure-activity relationships show that N 3 -bisubstitution increased the stability of these compounds. Moreover, in N 3 -monosubstituted and N 3 -bisubstituted compounds, stability is : N 1 -Methyl > N 1 -Allyl > N 1 -2-Chloroethyl > N 1 -Propargyl. |
