Neuroprotector Effect of Daily 8-Minutes of High-Intensity Interval Training in Rat Aβ1-42 Alzheimer Disease Model
| Autor: | Vania Marilande Ceccatto, Janaina Serra Azul Monteiro Evangelista, Roberta Cristina da Rocha-e-Silva, Jonathan Elias Rodrigues Martins, Paula Matias Soares, Francisco Sérgio Lopes Vasconcelos-Filho, Vitor Viana da Costa, Carlos A. Silva, Jannison Karlly Cavalcante Ribeiro, Welton Daniel Nogueira Godinho |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry medicine.medical_treatment Morris water navigation task Tropomyosin receptor kinase B medicine.disease Open field Interval training 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Neurology Internal medicine Medicine Neurology (clinical) Treadmill Alzheimer's disease business High-intensity interval training Saline 030217 neurology & neurosurgery |
| Zdroj: | Current Alzheimer Research. 17:1320-1333 |
| ISSN: | 1567-2050 |
| Popis: | Background: Alzheimer’s disease (AD) is the most common and irreversible neurodegenerative disorder, and amyloid peptide plays a central role in its pathogenesis. Physical training contributes as a beneficial adaptation to AD. However, these effects may be underestimated because much of the literature used fixed training prescription variables (intensity and volume) throughout the protocol. Moreover, researchers poorly understand whether chronic high-intensity interval training (HIIT) exerts similar effects on the brain tissue of individuals with AD. Objective: This study evaluated the effect of 8 minutes of HIIT with incremental overload in an AD model. Methods: Forty male Wistar rats were divided into four groups: an untrained Sham group, Sham trained group, Aβ1-42 (Alzheimer’s) untrained group, and Aβ1-42 (Alzheimer’s) trained group (n=10 rats per group). Animals underwent stereotactic surgery and received a hippocampal injection of Aβ1-42 or a saline solution. Seven days after surgery, two weeks of treadmill adaptation followed by a maximal running test (MRT) was performed. Then, animals were subjected to eight weeks of HIIT. Rats were sacrificed 24 h after the behavioral tests (open field and Morris water maze), hippocampal tissue was extracted to analyze the redox balance and BDNF/TrkB pathway, and neuritic plaques (NP) were detected by evaluating silver impregnation. Results: The AD trained group presented a physical capacity amelioration every two weeks and locomotor, learning, and memory improvements (p Conclusions: Based on these results, MRT was essential for an excellent chronic training protocol prescription and overload adjustment. Therefore, 8 minutes of HIIT daily for 8 weeks may reduce behavioral deficits by promoting a positive redox balance and increased activity of the BDNF/TrkB pathway that may contribute to NP attenuation. |
| Databáze: | OpenAIRE |
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