| Autor: |
Christina Niemeyer, J. Sun, Jian Hua Zheng, S. H. Leppla, Venkatachalapathi V. Yalamoori, N. Duesberry, Kalyanaraman Ramnarayan, Mark D. Shenderovich, M. G. de Luna, Darryl Rideout |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
Peptides: The Wave of the Future ISBN: 9789401039055 |
| DOI: |
10.1007/978-94-010-0464-0_310 |
| Popis: |
Bacillus anthracis, the cause of anthrax, poses a considerable danger because of its potential use as a weapon by military organizations and terrorist groups. Respiratory anthrax infections are almost invariably fatal despite antibiotic treatment. Anthrax lethal factor (LF) is a zinc metalloprotease [1] that cleaves mitogen-activating protein kinase kinase 1 and 2 (MAPKK1 and MAPKK2) followed by a series of biological reactions that leads to death [2]. Existing vaccines provide no protection against certain strains of Bacillus anthracis. The most potent inhibitor currently known is too weak to be useful in vivo [1]. A potent, non-peptide inhibitor of LF could be used to ameliorate and prevent the lethal effects of anthrax. Our approach involves identifying small molecules that mimic the substrate MAPKK1 in the calculated MAPKK/LF complex, which differs from traditional rational drug design methods. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
