Toxicity of para-aminobenzhydrazide and its effect on nuclei acid biosynthesis in cultures of normal and tumor cells

Autor:	Filov Va, Onishchuk Fd, Tret'iakov Av
Rok vydání:	1989
Předmět:	General Medicine Molecular biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound chemistry Biochemistry Biosynthesis Nucleic acid biosynthesis Toxicity Nucleic acid Hydrazine sulfate Cytotoxic T cell Hydrazine (antidepressant) Cytotoxicity
Zdroj:	Bulletin of Experimental Biology and Medicine. 107:236-238
ISSN:	1573-8221 0007-4888
Popis:	We have investigated cytotoxic action of p-aminobenzhydrazide and its influence on biosynthesis of nucleic acids in cultures of intact cells, tumor cells and intact cells stimulated by phytohemagglutinin. p-Aminobenzhydrazide is considered as a representative of hydrazine's derivatives (in particular, of hydrazine sulphate). We compare its action with that of a typical cytotoxic agent such as iododeoxyuridine. We have found that p-aminobenzhydrazide influences biosynthesis of nucleic acids in the same way as iododeoxyuridine. However it acts toxically on tumor cells though it is not toxic for intact cells so that its action is different as compared to that of cytotoxic agents. Specific toxic action of aminobenzhydrazide on tumor cells may be due to the enhancement of antitumor activity substances of this compound and absence of such enhancement of side toxic effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::601c3f0f4c559320488ad91bf75b89e0 https://doi.org/10.1007/bf00833814 Zobrazit plný text záznamu Full text from SpringerLink