| Autor: |
Anupama Shahane, Reshmi Raveendran, Mildred Kwan, Annemarie Schorpion, Alfredo C. Rivadeneira |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Rare Rheumatic Diseases of Immunologic Dysregulation ISBN: 9783319991382 |
| DOI: |
10.1007/978-3-319-99139-9_7 |
| Popis: |
Remitting seronegative symmetrical synovitis and pitting edema (RS3PE) is an uncommon condition that is characterized as an acute polysynovitis associated with pitting edema that tends to affect individuals who are over 50 years of age. This condition was first described by McCarty et al. in 1985 and although now usually thought of as a separate entity was originally thought to represent a subset of late onset rheumatoid arthritis (LORA). The controversy over the last 30 years as to whether RS3PE is a separate entity or forms a part of a clinical spectrum that includes LORA and polymyalgia rheumatica (PMR) is due to the similarities in clinical and demographic characteristics that are shared by these conditions. Additionally, RS3PE is also considered a paraneoplastic condition as it is often associated with malignancy. In this chapter, we will discuss the epidemiological and clinical characteristics of RS3PE, associated conditions including malignancy, diagnosis and management, as well as current data on mechanism of disease pathogenesis including areas of ongoing research and future directions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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