| Popis: |
Five analogs of human insulin with d -Cys in different positions (A 6 , A 7 , A 11 , A 6+11 , B 7 ) have been synthesized by the fragment condensation approach, combined with selective disulfide formation. All of them have physicochemical properties noticeably different from those of human insulin. They possess very low biological activity (0.03−1.2%, glucose oxidation in rat fat cells). In contrast, the potency for antibody binding ranges from 7 to 70% of that of insulin. The two analogs with d -Cys in positions A 6 and A 7 have been obtained in crystalline form. |
