Case Study: Distribution and Redistribution of Levomepromazine and its Metabolites in a Fatal Poisoning

Autor:	B. Bujak-Gizycka, J. Kunz, M. Kłys, W. Klementowicz
Rok vydání:	2003
Předmět:	Levomepromazine Toxicology chemistry.chemical_compound Chromatography chemistry medicine Xenobiotic Pathology and Forensic Medicine medicine.drug
Zdroj:	Canadian Society of Forensic Science Journal. 36:77-88
ISSN:	2332-1660 0008-5030
DOI:	10.1080/00085030.2003.10757555
Popis:	The subject of the study is a fatal poisoning with levomepromazine. A toxicological investigation carried out by means of the liquid chromatographic method with mass detection (LC/MS) revealed levomepromazine and its 24 metabolites in postmortem specimens in various concentrations depending on the specimen tested. The study was undertaken not only for judicial evidence, but also to investigate whether any changes occur in the concentrations of xenobiotics found in blood during the postmortem interval. The investigation confirmed such differences in xenobiotic concentrations, proving that the passive diffusion of xenobiotics in a body takes place.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5fec2c8dccaa8599797673f061b018c9 https://doi.org/10.1080/00085030.2003.10757555 Zobrazit plný text záznamu