How protoporphyrinogen IX oxidase inhibitors and transgenesis contribute to elucidate plant tetrapyrrole pathway
| Autor: | Veronica Ambrosini, Stéphanie Leroy-Lhez, Catherine Riou, Mohammad Issawi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
chemistry.chemical_classification 0303 health sciences fungi Diphenyl ether food and beverages Protoporphyrinogen IX Oxidase General Chemistry 01 natural sciences Tetrapyrrole Protoporphyrinogen IX Transgenesis 03 medical and health sciences chemistry.chemical_compound Enzyme Biochemistry chemistry Pyrimidinedione Protoporphyrinogen oxidase 030304 developmental biology 010606 plant biology & botany |
| Zdroj: | Journal of Porphyrins and Phthalocyanines. 23:419-426 |
| ISSN: | 1099-1409 1088-4246 |
| DOI: | 10.1142/s1088424619300076 |
| Popis: | Several families of herbicides, especially diphenyl ether (DPE) and pyrimidinedione, target the plant tetrapyrrole biosynthesis pathways and in particular one key enzyme, protoporphyrinogen IX oxidase (PPO). When plants are treated with DPE or pyrimidinedione, an accumulation of protoporphyrin IX, the first photosensitizer of this pathway, is observed in cytosol where it becomes very deleterious under light. Indeed these herbicides trigger plant death in two distinct ways: (i) inhibition of chlorophylls and heme syntheses and (ii) a huge accumulation of protoporphyrin IX in cytosol. Recently, a strategy based on plant transgenesis that induces deregulation of the tetrapyrrole pathway by up- or down-regulation of genes encoding enzymes, such as glutamyl-[Formula: see text]RNA reductase, porphobilinogen deaminase and PPO, has been developed. Against all expectations, only transgenic crops overexpressing PPO showed resistance to DPE and pyrimidinedione. This herbicide resistance of transgenic crops leads to the hypothesis that the overall consumption of herbicides will be reduced as previously reported for glyphosate-resistant transgenic crops. In this review, after a rapid presentation of plant tetrapyrrole biosynthesis, we show how only PPO enzyme can be the target of DPE and how transgenic crops can be further resistant not only to herbicide but also to abiotic stress such as drought or chilling. Keeping in mind that this approach is mostly prohibited in Europe, we attempt to discuss it to interest the scientific community, from plant physiologists to chemists, who work on the interface of photosensitizer optimization and agriculture. |
| Databáze: | OpenAIRE |
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