Synthesis and characterization of peptide nucleic acid–platinum nanoclusters
| Autor: | Rajeev R. Pandey, Mihrimah Ozkan, Roger K. Lake, Cengiz S. Ozkan, Krishna V. Singh, Chunglin Tsai, Xu Wang, G. T. Senthil Andavan |
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| Rok vydání: | 2006 |
| Předmět: |
Nanostructure
Peptide nucleic acid musculoskeletal neural and ocular physiology Mechanical Engineering Analytical chemistry chemistry.chemical_element Nanoparticle Bioengineering General Chemistry Combinatorial chemistry chemistry.chemical_compound chemistry Mechanics of Materials Transmission electron microscopy General Materials Science Molecular orbital Density functional theory Chemical binding Electrical and Electronic Engineering Platinum |
| Zdroj: | Nanotechnology. 17:1177-1183 |
| ISSN: | 1361-6528 0957-4484 |
| Popis: | Peptide nucleic acid (PNA) is an analogue of deoxyribonucleic acid (DNA) and possesses a neutral backbone that affords stronger hybridization, greater stability and higher specificity in base pairing. However, it has not been explored as much as DNA in self-assembling functional nanostructures or nanoelectronic devices. We report here for the first time the metallization of PNA with platinum (Pt) nanoparticles via chemical binding, reduction and deposition. Pt ions from a precursor salt solution are allowed to bind over the PNA fragments followed by a reduction and then growth into metal nanoparticles. PNA–Pt complexes form chains several hundred nanometres in length and by varying the duration of chemical reduction step, the dimension of the Pt nanoparticles can be controlled. The structural features and chemical composition of PNA–Pt nanoparticles have been characterized via scanning electron microscopy, transmission electron microscopy and Fourier transform-infrared spectroscopy. These results are also supported by modelling and analysis of the nature of high-lying molecular orbitals on PNA using density functional theory (DFT) method. |
| Databáze: | OpenAIRE |
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