Overexpression of c-erbB-2 protein and locoregional recurrence in node-positive breast cancer
| Autor: | C. Klintenberg, S. Sullivan, Olle Stål |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.diagnostic_test business.industry Matched control General Medicine Odds ratio Logistic regression medicine.disease Flow cytometry Breast cancer medicine.anatomical_structure Hormone receptor Internal medicine Medicine Surgery business C erbb 2 protein Lymph node |
| Zdroj: | The Breast. 6:354-360 |
| ISSN: | 0960-9776 |
| DOI: | 10.1016/s0960-9776(97)90692-5 |
| Popis: | The expression of c-erbB-2 protein was analysed in tumour specimens from 49 node-positive breast cancer patients with locoregional recurrence and 147 matched control patients without such events. The level of c-erbB-2 expression was quantified together with DNA content by flow cytometry. Odds ratios were calculated by matched logistic regression analysis. Nearly half of the tumours in the recurrence group (45%) showed elevated levels of c-erbB-2 compared to 25% of those in the control group. The odds ratio comparing patients with and without locoregional relapse increased significantly with increasing levels of c-erbB-2 expression. c-erbB-2 expression was a statistically significant indicator in addition to the number of lymph node metastases. Tumour size, hormone receptor status and S-phase fraction, which are known indicators of distant recurrence, were not independently associated with locoregional relapse. S-phase fraction, but not cerbB-2 overexpression, correlated with survival following locoregional recurrence. |
| Databáze: | OpenAIRE |
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