| Autor: |
Amandine Hue-Bigé, Bérengère François, Florence Casagrande, Julie Oertel, Mayerus Mathilde, Sergio Eleni Dit Trolli |
| Rok vydání: |
2023 |
| DOI: |
10.21203/rs.3.rs-2817307/v1 |
| Popis: |
Objective The diagnosis of early-onset neonatal sepsis (EOS) remains difficult. The early administration of antibiotic therapy though not without risk is still the most common practice. The main aim was to study the effect of a new algorithm for EOS, which includes the level of procalcitonin (PCT) in umbilical cord blood, on the exposure to antibiotic therapy of premature neonates of gestational age below 33 weeks of gestation who show signs of a risk of EOS.Materials and methods This is a monocentric, observational and retrospective study “before and after” of the evaluation of daily professional practices. The study was performed over two periods from the 1st of May to the 30th of November 2015, for the group of neonates not receiving PCT “no PCT” and from the 1st of November 2016 to the 30th of May 2017 for the group of neonates receiving PCT “PCT”. The duration and dose of antibiotic therapy provided as well as the morbidity and mortality were compared.Results Sixty neonates were included in the “no PCT” group and 54 in the “PCT” group. Antibiotic therapy was stopped after 24 hours for 18 neonates in the “PCT” group and 4 in the “no PCT” group (p = 0.001), and after 48 hours for 26 neonates in the “PCT” group and 10 in “no PCT” group (p = 0.0009). The average number of days of antibiotics was 3 for the “no PCT” group and one for the “PCT” group.Conclusion The implementation of a new decision making algorithm including PCT in the umbilical cord blood of preterm neonates at less than 33 weeks of gestation significantly reduced exposure to antibiotics without modifying mortality or morbidity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
