Effects of polymorphism (plm) in interleukin (IL) 1 and IL10 genes on surgery outcome in ovarian cancer (OC)

Autor:	Radoslav Chekerov, Elena-Ioana Braicu, Pengming Sun, P. Nuernberg, Dominique Koensgen, Cristina Pirvulescu, Jalid Sehouli, Alexander Mustea, M. R. Toliat, Werner Lichtenegger
Rok vydání:	2006
Předmět:	Cancer Research Interleukin 10 Oncology business.industry Interleukin 1 family Surgery outcome Medicine Interleukin business Ovarian cancer medicine.disease Bioinformatics Gene
Zdroj:	Journal of Clinical Oncology. 24:20094-20094
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2006.24.18_suppl.20094
Popis:	20094 Background: IL1 and IL10 are overexpressed in 55% to 98% of advanced epithelial OC. Different studies demonstrated IL1 and IL10 as independent prognostic factors for OC. This study was performed to investigate the influence of plms of IL-1A, IL-1B and IL-10 gene on the occurrence tumor biology of OC. Methods: In a prospective, monocentric, case-control study 147 pts with OC (71 pts with primary OC and 77 pts with recurrent OC) and 129 pts with no history of malignancies were genotyped for plms of the IL-1 gene (IL-1A -889 T/C and IL-1B -511 C/T promoter) and IL-10 gene (IL-10 -1082 G/A, -819 C/T and -592 C/A). All pts were collected within Tumor bank Ovarian Cancer Project. Genomic DNA fragments were amplified by PCR and the allele sequences were obtained by pyrosequencing. We analyzed significance using the Chi-Square by Pearson and Fisher’s exact test. Statistical significance was determined by Mann-Whitney test. A two-tailed p value No significant financial relationships to disclose.
Databáze:	OpenAIRE
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