Progestin in Control of Human Uterine Contractions. Significance in Prevention of Habitual and Threatened Spontaneous Abortion
| Autor: | Julius E. Lackner, Frederick H. Falls, Leon Krohn |
|---|---|
| Rok vydání: | 1935 |
| Předmět: |
Gynecology
medicine.medical_specialty urogenital system business.industry Obstetrics medicine.drug_class Uterus Pituitrin Abortion General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure medicine Previous pregnancies business Corpus luteum Progestin reproductive and urinary physiology Post partum Hormone |
| Zdroj: | Experimental Biology and Medicine. 32:1451-1454 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-32-8131p |
| Popis: | The hormone progestin, extracted from the corpus luteum, has been used experimentally in the lower animals to inhibit uterine contractions. Its use clinically has been reported in women who were aborting and in those with a history of habitual abortion. The apparent reason for its effectiveness in such cases is its antagonistic action to the oxytoxic action of pituitrin. We reported1 a series of 19 cases, some of which were threatened abortions and some habitual abortions. These women had lost 69% of their babies in 38 previous pregnancies under ordinary management, while the same women lost only 26% of their babies when treated with progestin, but without morphine or other sedative.To test out the effect of progestin on the contractions of the human uterus, a metreurynter bag was introduced into the uterus on the seventh day post partum and inflated sufficiently to stimulate weak uterine contractions, according to the method of Moir.2 The bag was connected to a recording tambour by a long rubber tubing. ... |
| Databáze: | OpenAIRE |
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