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Molecular studies of influenza virus isolated during 1996–2000, from 0- to 85-year-old patients with influenza-like illness living in the southern, southeastern, central western, northern and northeastern regions of Brazil, are described. Molecular epidemiology of the influenza virus demonstrated that strains H1N1 (A/Texas/36/91, A/Bayern/07/95, A/Taiwan/01/86, A/New Caledonia/20/99 and A/Johannesburg/82/99), detected from 1996 through 2000, evolved gradually from the strain A/Taiwan/1/86. Similarly, the strain H3N2 (A/Alaska/10/95, A/Johannesburg/33/94, A/Wuhan/35/95, A/Sydney/05/97, A/Moscow/10/99 and A/Panama/2007/99) seems to have evolved gradually from the ancestral strain A/Beijing/32/92. With regard to influenza virus type B, the strains B/Beijing/184/93 and B/Sichuan/279/99, evolved gradually from the ancestral B/Yamagata/26/88. Thus, molecular studies have showed that influenza viruses circulating from 1996 to 2000 in Brazil were similar to those on other continents. In addition, this investigation emphasizes the fundamental role of surveillance in order to select appropriate influenza strains for Southern Hemisphere vaccine composition. |
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