Various doses of cisplatin (DDP) combined with multi-drug chemotherapy for advanced malignant solid tumor
| Autor: | Yan Sun, Guangqing Wu, Qing Li, Mei Su, Hui Xiong, Cai Wang, Feng-yi Feng, Jinwan Wang, Zhou Jc, Qilu Wang |
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| Rok vydání: | 1990 |
| Předmět: |
Drug
Cisplatin Cancer Research medicine.medical_specialty Chemotherapy business.industry media_common.quotation_subject medicine.medical_treatment Combination chemotherapy Pharmacology Gastroenterology Oncology Medicine public health Internal medicine Toxicity medicine Advanced Malignant Solid Tumor business media_common medicine.drug |
| Zdroj: | Chinese Journal of Cancer Research. 2:56-59 |
| ISSN: | 1000-9604 |
| Popis: | Two hundred and thirty-six patinets with various advanced malignant solid tumors treated by combined chemotherapy with routine doses of cisplatin (DDP) from 1980 to 1986 are presented. According to different doses of cisplatin everyday, the patients were divided into 4 groups: (1) 20 mg/day×4–5, 80 cases; (2) 30 mg/day× 3–5, 91 cases; (3) 40 mg/day 3–4, 37 cases; (4) 50 mg/day×2–3, 28 cases. Each group was repeated for 3 weeks. The effect and toxicity were analysed and compared with 22 cases treated by single DDP in 1975. The response (CR+PR) rate was 39.2% in 194 evaluated patients. The response rate was similar in group 20 mg and single DDP (29.2% and 27.3%). The response rate was lower than that of group 30 mg, 40 mg, and 50 mg 43.4% and 50%) (P |
| Databáze: | OpenAIRE |
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