| Popis: |
Glycosylation by classic definition is a serial biochemical and enzymatic addition that a glycosyl donor attached to the hydroxyl or functional group of glycosyl acceptor, such as protein or lipid, to form a branch structure. Emerging evidences that aberrant expression of glycosylation-related genes (glycogenes) resulting in altered glycosylation targets have been identified its importance in tumor progression including invasion, migration, proliferation, angiogenesis, and metastasis, while all these components are highly correlated with clinical diagnosis and treatment. To facilitate our understanding of such genes participated in tumor progression, we construct a database OncoDB.Glycogene for developing new theranostic targets of cancers and demonstrate our text-mining based glycogene corpus with the combination of The Cancer Genome Atlas (TCGA) data to draw the interaction between abnormal glycosylation with tumor from integrated genomic viewpoints. We first showed that the coverage of 3026 glycogenes from OncoDB.Glycogene are more comprehensive and unique than other public glycogene resources with inclusion of biosynthesis, metabolism and functional participation of glycosylation such as nucleotide sugar transporter, precursors, or surveillance chaperon, from the aspects of pathway or either Gene Ontology similarity. And to comprehensively reveal glycogenes participated in cancers, we integrated cancer omics data such as copy number, methylation, gene expression with clinical features, i.e. patient survival information, from TCGA with user friendly webpage interfaces for graphic and pathway network displays. With our integrative effort we should improve our knowledge how glycosylation engage in tumor progression and facilitate development of theranostic biomarkers of cancers. |
