| Autor: |
de Fenos Om, Acosta Nd, José Alberto Castro, de Castro Cr, Gómez Mi, de Ferreyra Ec |
| Rok vydání: |
1975 |
| Předmět: |
|
| Zdroj: |
Toxicology and Applied Pharmacology. 32:101-108 |
| ISSN: |
0041-008X |
| DOI: |
10.1016/0041-008x(75)90199-4 |
| Popis: |
In agreement with previous reports from other laboratories, the fed rats are more resistant to the toxic action of CCl4 than rats starved overnight. This preventive effect of feeding does not merely reflect a delay in the time for damage to appear, since the protection is even more pronounced at 72 than at 24 hr. The similarity in CCl4 concentrations in the livers of fed and fasted rats excludes an effect due to a decreased absorption of the hepatotoxin. Irreversible binding of 14CCl4 to liver microsomal lipids and lipid peroxidation are only slightly decreased in the livers of fed rats when compared to that of fasted rats. These findings correlate with the similarity of the sleeping time, cytochrome P-450 content and cytochrome P-650 reductase activity in both groups. Preventive effects are apparently due to an interference in the events occurring between CCl4 activation or lipid peroxidation and the resulting damage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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