Determination of body spaces and renal clearances with yttrium chelates in man
| Autor: | Hiram E. Hart, Herta Spencer, Edward Greenwald, Daniel Laszlo, Betty Rosoff |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
Kidney
Radiation Chromatography animal diseases Inulin Radiochemistry chemistry.chemical_element Total body Yttrium respiratory system chemistry.chemical_compound medicine.anatomical_structure Nuclear Energy and Engineering chemistry Clinical investigation Diethylenetriamine cardiovascular system medicine Radiology Nuclear Medicine and imaging Chelation circulatory and respiratory physiology Clearance |
| Zdroj: | The International Journal of Applied Radiation and Isotopes. 8:198-204 |
| ISSN: | 0020-708X |
| DOI: | 10.1016/0020-708x(60)90139-3 |
| Popis: | Diethylenetriamine pentaacetic acid (DTPA) is a chelate with a strong affinity for certain metals. Since the yttrium complex of this chelate (Y-DTPA) is very stable, can be readily labeled with radioactive yttrium (Y90 or Y91) and is quantitatively excreted by the kidney within 24 hr, this compound was used for renal clearance and space of distribution studies in 7 patients. The renal clearance of Y-DTPA was almost identical to that of inulin in two patients and was 33 per cent higher in a third patient, the ratio of CY-DTPA/CCr ranging from 1·27 to 1·89 in the 5 patients so studied. The Y-DTPA space was studied in 5 patients employing a 4 hr constant infusion and in 3 of these, 8–22 hr infusions were also given. The Y-DTPA space varied from 16·0 to 23·2 per cent of total body weight. Y-DTPA and inulin spaces were determined simultaneously in two patients. The Y-DTPA space was 9 per cent and 27 per cent greater than the inulin space for the 2 patients, respectively. The significance of the results obtained and the applicability of this method for clinical investigation will be discussed. |
| Databáze: | OpenAIRE |
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