Réirradiation des cancers des voies aérodigestives supérieures
| Autor: | Joël Guigay, D. Lam Cham Kee, A. Bozec, E. Saâda-Bouzid, K. Benezery, F. Peyrade, Anne Sudaka, Olivier Dassonville, L. Krebs, Gilles Poissonnet, Jérôme Doyen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Chemotherapy
medicine.medical_specialty business.industry medicine.medical_treatment medicine.disease Head and neck squamous-cell carcinoma 030218 nuclear medicine & medical imaging Surgery Radiation therapy 03 medical and health sciences Regimen 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Total dose medicine Radiology Nuclear Medicine and imaging Radiology business Head and neck Severe toxicity Proton therapy |
| Zdroj: | Cancer/Radiothérapie. 21:521-526 |
| ISSN: | 1278-3218 |
| Popis: | Locoregional relapse in previously irradiated region for head and neck tumours is associated with a bad locoregional and distant prognosis. Reirradiation might be exclusive, or feasible in addition with surgery and/or chemotherapy, according to histopronostic factors. Data show that reirradiation is feasible with some severe toxicity due to the bad prognosis of this situation. Hyperfractionnated regimen with split course or normofractionnated regimen without split course are possible with similar efficacy. If tumour size is small, stereotactic ablative radiotherapy may be considered, and if the treatment centre has proton therapy, it could be proposed because of better organs at risk sparing. There is no standard regarding reirradiation schedules and several trials have to be done in order to determine the best technique. Nevertheless, it is agreed that a total dose of 60Gy (2Gy per fraction) is needed. Other trials testing the association with new systemic agents have to be performed, among them agents targeting the PD1/PD-L1 axis. |
| Databáze: | OpenAIRE |
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