Exposures to Atmospheric PM10 and PM10–2.5 Affect Male Semen Quality: Results of MARHCS Study
| Autor: | Jia Cao, Ziyuan Zhou, Jiaojiao Liu, Lianbing Li, Lin Ao, Jinyi Liu, Linping Huang, Hongqiang Chen, Qing Chen, Lei Sun, Niya Zhou, Huan Yang, Ling Li, Zhihong Cui, Xiaogang Wang, Peng Zou, Changtan Jiang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.diagnostic_test business.industry Physiology Regression analysis General Chemistry 010501 environmental sciences Semen analysis Affect (psychology) complex mixtures 01 natural sciences Sperm 03 medical and health sciences Semen quality 030104 developmental biology Environmental Chemistry Medicine DNA fragmentation business Testosterone Sperm motility 0105 earth and related environmental sciences |
| Zdroj: | Environmental Science & Technology. 52:1571-1581 |
| ISSN: | 1520-5851 0013-936X |
| DOI: | 10.1021/acs.est.7b05206 |
| Popis: | Studies have shown that the effects of ambient particulate matter (PM) may be related to particle's size. However, results on the relationships between different PM and reproductive health are controversial. To explore the impacts of various PM fractions on male reproductive health, a total of 796 eligible subjects recruited in 2013 baseline investigation. In addition, there were 656 (82.4%) and 568 (71.3%) subjects participated follow-up surveys in 2014 and 2015, respectively. We used multivariable regression analysis and mixed-effect model to investigate the associations between air pollutants PM10, PM10-2.5, and PM2.5 exposures and semen quality, sperm DNA fragmentation and serum reproductive hormones of subjects. In the preliminary regression analysis, PM10, PM10-2.5, and PM2.5 exposure all associated with sperm concentration, morphology, sperm high DNA stainability (HDS), serum estradiol and testosterone levels. However, in mixed models, we only found that PM10 exposure were negatively associated with sperm normal morphology (95% CI: -14.13, -24.47) but positively associated with sperm progressive motility (95% CI: 23.00, 8.49), and PM10-2.5 exposure was inversely associated with sperm concentration (95% CI: -9.06, -27.31) after multiplicity adjustment. Our results provide the evidence that air PM10 and PM10-2.5 exposures, not PM2.5, are risk factors of semen quality. |
| Databáze: | OpenAIRE |
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