Efficacy of intra-articular polynucleotides associated with hyaluronic acid vs hyaluronic acid alone in the treatment of knee osteoarthritis
| Autor: | Ruilong Chang, Ning Zuo, Ningbo Lei, Qiang Li, Yubiao Gu, Lei Zhang, Chenxu Yang |
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| Rok vydání: | 2020 |
| Předmět: |
Research design
medicine.medical_specialty business.industry MEDLINE General Medicine Osteoarthritis Cochrane Library medicine.disease law.invention Clinical trial 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial chemistry law 030220 oncology & carcinogenesis Internal medicine Meta-analysis Hyaluronic acid Medicine 030212 general & internal medicine business |
| Zdroj: | Medicine. 99:e20689 |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000020689 |
| Popis: | Background The reduced range of motion and pain are the most characteristic clinical features of osteoarthritis (OA). Hyaluronic acid (HA), which is one of the infiltrative therapies for OA treatment, and polynucleotides (PNs), which is a DNA-derived macromolecule favored cell growth and collagen production, are an ongoing debate in clinical effectiveness. Methods We plan to perform a systematic review and meta-analysis of randomized clinical trial to evaluate efficacy of intra-articular polynucleotides associated with hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis. We will search PubMed, EMBASE, Cochrane Library using a comprehensive strategy. The related conference proceedings and reference lists of the included studies will also be checked to identify additional studies. Two reviewers will screen retrieved records, extract information and assess the risk of bias independently. Stata v15.1 software will be used to conduct data synthesis. Results This study will be submitted to a peer-reviewed journal for publication. Conclusion We hope it will provide a relatively comprehensive reference for clinical practice and future relevant clinical trials. Ethics and dissemination Ethics approval and patient consent are not required, as this study is a systematic review and meta-analysis. Prospero registration number CRD42020167678. |
| Databáze: | OpenAIRE |
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