Mechanism of action of nonachlazine on the blood supply and activity of the heart
| Autor: | Chumburidze Vb, G. A. Markova, Kaverina Nv, R. Griglewski, A. I. Basaeva |
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| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Cardiac output Glycogenolysis business.industry General Medicine Metabolism General Biochemistry Genetics and Molecular Biology Glycogen phosphorylase Endocrinology Mechanism of action Internal medicine cardiovascular system Cardiology medicine Liberation Blood supply medicine.symptom business Anaerobic exercise |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 80:1319-1321 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Nonachlazine (10 mg/kg, intravenously) has a biphasic effect on cardiac activity. A short phase of weakening of cardiac activity is followed by a marked increase in the cardiac output and contractile function of the myocardium. The increase in the blood supply and activity of the heart coincides in time with the accumulation of noradrenalin in the myocardium and an increase in phosphorylasea. β-Adrenoblockers prevent the development of these effects. It is postulated that the effectiveness of nonachlazine in ischemic heart disease is connected with its ability to activate adrenergic mechanisms of glycogenolysis control, leading to switching of metabolism in the myocardium to the anaerobic pathway of energy liberation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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