Evaluation of protective effect of aqueous extract of Phyllanthus emblica fruit on duodenum mucosa in experimentally induced diarrhea in albino Wistar rats
| Autor: | D. B. Mondal, D. K. Sharma, V. K. Gupta |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Loperamide biology 040301 veterinary sciences business.industry Glutathione peroxidase 04 agricultural and veterinary sciences Pharmacology Pathology and Forensic Medicine 0403 veterinary science Lipid peroxidation Superoxide dismutase Diarrhea chemistry.chemical_compound medicine.anatomical_structure Intestinal mucosa chemistry Duodenum medicine biology.protein Defecation Anatomy medicine.symptom business medicine.drug |
| Zdroj: | Comparative Clinical Pathology. 28:297-303 |
| ISSN: | 1618-565X 1618-5641 |
| DOI: | 10.1007/s00580-018-2830-2 |
| Popis: | Phyllanthus emblica fruit is an excellent source of antioxidants which is widely used for different gastric ailments in Ayurveda and traditional herbal medicine. Thus, the aim of this study was to investigate the antioxidative and protective role of aqueous extract of Phyllanthus emblica fruit (AEPEF) on intestinal mucosa against castor oil-induced diarrhea. Rats were randomly divided into five groups (N = 6). After acclimatization of 7 days, group I (control) and group II (loperamide) were given distilled water @ 20 ml/kg body weight (BW) orally whereas rats of group III, group IV, and group V received AEPEF @ 200 mg, 400 mg, and 600 mg/kg BW respectively, daily for 14 days. On the 15th day, diarrhea was induced with 1 ml castor oil to each rat orally. Onset time of diarrhea and percentage inhibition of defecation revealed significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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