THE EFFECT OF VALPROIC ACID ON FATTY ACID OXIDATION BEFORE AND AFTER L-CARNITINE SUPPLEMENTATION
| Autor: | Piero Rinaldo, James H Tonsgard, Brian D Kossak, Dale A Schoeller, Douglas A Gage, Eberhard Schmidt-Sommerfeld, Zhi-Heng Huang, Duna Penn |
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| Rok vydání: | 1992 |
| Předmět: |
Valproic Acid
medicine.medical_specialty Creatinine Chemistry Metabolite Urine Excretion chemistry.chemical_compound Endocrinology Biochemistry Renal physiology Internal medicine Pediatrics Perinatology and Child Health medicine lipids (amino acids peptides and proteins) Carnitine Beta oxidation medicine.drug |
| Zdroj: | Pediatric Research. 32:625-625 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-199211000-00124 |
| Popis: | Urinary metabolites and 13CO2-production from 13C-octanoic acid were studied in 12 patients (3-19 y.o.) with seizure disorders before and during valproic acid (VPA) therapy without and with L-carnitine supplementation. Only one patient had a decreased plasma level of free carnitine (FC) during VPA. Urinary FC concentrations were positively correlated with serum VPA levels (p |
| Databáze: | OpenAIRE |
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