Temozolomide Cocrystals Exhibit Drug Sensitivity in Glioblastoma Cells

Autor:	Ashwini Nangia, V. Lavanya, K. Kanakaraju, Kusuma
Rok vydání:	2014
Předmět:	Drug Temozolomide Chemistry media_common.quotation_subject General Physics and Astronomy Pharmacology medicine.disease Cocrystal chemistry.chemical_compound Cell culture Succinic acid medicine Cytotoxic T cell U87 medicine.drug media_common Glioblastoma
Zdroj:	Proceedings of the National Academy of Sciences, India Section A: Physical Sciences. 84:321-330
ISSN:	2250-1762 0369-8203
DOI:	10.1007/s40010-014-0142-8
Popis:	Temozolomide is the only drug approved for the treatment of malignant brain tumors. The sensitivity of Temozolomide-Succinic acid and Temozolomide-Oxalic acid cocrystals (TMZ-SA and TMZ-OA) in inhibiting the proliferation and growth of human glioblastoma malignant cell lines U373, U87 and LN18 is comparable to the reference drug. Both TMZ-SA and TMZ-OA cocrystals are stable to long term storage (white color powder) whereas TMZ becomes tan brown within 2 months (indicative of degradation). These pharmaceutical cocrystals combine the desirable features of hyrolytic stability, good dissolution and cytotoxic activity for further preclinical studies. Inhibition of human glioblastom cell line U87 proliferation by Temozolomide-Succinic acid cocrystal. .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5f917655684b8857e4d3db8ad9dd1835 https://doi.org/10.1007/s40010-014-0142-8 Zobrazit plný text záznamu Full text from SpringerLink