Hormonal Therapy for Hypopituitarism ☆
| Autor: | J.P. Monson, F.M. Swords, P. V. Carroll, W. M. Drake |
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| Rok vydání: | 2017 |
| Předmět: |
endocrine system
medicine.medical_specialty Somatotropic cell business.industry Pituitary tumors Pituitary apoplexy Hypopituitarism medicine.disease Gonadotropic cell medicine.anatomical_structure Endocrinology Anterior pituitary Posterior pituitary Internal medicine medicine Corticotropic cell business hormones hormone substitutes and hormone antagonists |
| Popis: | Different etiologies of hypopituitarism may give rise to distinct patterns of hormone deficiency, all causes may eventually lead to panhypopituitarism. Typically, pituitary tumors lead to gradual loss of anterior pituitary hormones with disinhibition of prolactin release. Progressive pituitary failure related to tumor or irradiation results in growth hormone (GH) deficiency, followed by sequential loss of the other hormones of the anterior pituitary: luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and finally adrenocorticotropin hormone (ACTH). Loss of posterior pituitary function resulting in diabetes insipidus rarely occurs as a direct result of a pituitary mass lesion, with pituitary metastasis being an important exception. Deficiency of antidiuretic hormone (ADH) commonly occurs in hypothalamic lesions, and transient or permanent ADH deficiency may complicate trauma to the pituitary fossa, as seen in surgery and pituitary apoplexy. This chapter discusses the etiologies of hypopituitarism and the optimal approach to hormone replacement therapy for ACTH, TSH, LH/FSH, GH and ADH deficiency. |
| Databáze: | OpenAIRE |
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