Pathological Studies on Corynebacterial Ulcerative Entero-Colitis in Rats Treated with ACTH

Autor:	Hidemasa Ogawa, Akimoto Yamada
Rok vydání:	1975
Předmět:	Pathology medicine.medical_specialty Kidney Lung business.industry Provocation test Intraperitoneal inoculation General Medicine medicine.disease Lesion Cecum medicine.anatomical_structure medicine Colitis medicine.symptom business Pathological
Zdroj:	EXPERIMENTAL ANIMALS. 24:151-155_4
ISSN:	1884-4170 0007-5124
DOI:	10.1538/expanim1957.24.4_151
Popis:	Ulcerative entero-colitis was developed in 6-week-old male Sprague-Dawley rats treated daily with ACTH (4 mg/kg. s. c.) as well as necrotic purulent lesions in liver, kidney, lung or heart. Incidence of ulcerative lesions was 6.3% in Farm-A rats and 56% in Farm-B rats. Although ulcerative lesions were mostly observed in cecum, the similar lesions were also detected in distal ileum or proximal colon in some cases. Histologically, the lesions were characterized by focal necrosis demarcated from surrounding normal tissue containing a number of clumps of bacteria and cellular debris. Bacteriological examination revealed that provocation of Coryne-bacterium kutscheri by ACTH-treatment resulted in appearance of the lesions. By means of intravenous or intraperitoneal inoculation with the strain isolated from lesion similar lesions were produced in the cecum of inoculated rats under the ACTH-treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5f8c51f3db68c9e6498373f7eefa7821 https://doi.org/10.1538/expanim1957.24.4_151 Zobrazit plný text záznamu