Significant correlation between renal 123I-metaiodobenzylguanidine scintigraphy and muscle sympathetic nerve activity in patients with primary hypertension

Autor: Yoshitaka Okabe, Shuichi Kaneko, Takuto Hamaoka, Hiroshi Furusho, Yuji Okuyama, Hideki Tokuhisa, Shinro Matsuo, Takeshi Kato, Shinichiro Takashima, Soichiro Usui, Masayuki Takamura, Hisayoshi Murai, Yusuke Mukai, Oto Inoue
Rok vydání: 2017
Předmět:
Zdroj: Journal of Nuclear Cardiology. 24:363-371
ISSN: 1532-6551
1071-3581
DOI: 10.1007/s12350-016-0760-4
Popis: Iodine-123 metaiodobenzylguanidine (123I-MIBG) scintigraphy is used as a noninvasive imaging method for assessing cardiac sympathetic nerve activity. We tested the hypothesis that renal 123I-MIBG imaging is correlated with muscle sympathetic nerve activity (MSNA) in patients with primary hypertension. Thirty-one consecutive patients with primary hypertension were included. Multiunit MSNA was recorded from the peroneal nerve to evaluate direct efferent sympathetic nerve activity. Planar renal and cardiac 123I-MIBG images were acquired. Early and delayed kidney-to-mediastinum ratio (K/M), early and delayed heart-to-mediastinum ratio (H/M), and washout rates (WR) were calculated. In 27 of 31 patients, blood pressure was controlled on antihypertensive medication. Mean systolic and diastolic blood pressures were 118 ± 18 and 67 ± 15 mmHg, respectively. Although early and late K/M and H/M were not significantly correlated with MSNA, both cardiac and average renal WR were significantly correlated with MSNA (r = 0.45, P = .0035 and r = 0.68, P
Databáze: OpenAIRE
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