Synthesis, Characterization, and Anti-inflammatory Activity of Novel Isoxazolyl-4-(2-oxo-2,3-dihydro-1H -3-indolyl)pyrrole-3-carboxylates

Autor:	Rajanarendar Eligeti, Srinivas Reddy Malladi, Nagaraju Dharavath, Ramakrishna Saini
Rok vydání:	2017
Předmět:	Ethanol 010405 organic chemistry medicine.drug_class Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Anti-inflammatory 0104 chemical sciences Catalysis chemistry.chemical_compound medicine Organic chemistry Pyrrole
Zdroj:	Journal of Heterocyclic Chemistry. 54:2830-2837
ISSN:	0022-152X
DOI:	10.1002/jhet.2888
Popis:	A series of novel isoxazolyl-4-(2-oxo-2,3-dihydro-1H-3-indolyl)pyrrole-3-carboxylates (17a–i) were synthesized by a three-component reaction of 4-amino-3-methyl-5-styrylisoxazole 14, β-keto ester 15, and 3-phenacylideneoxindole 16, in the presence of CAN catalyst in ethanol. The structures of the synthesized compounds have been established on the basis of spectral and analytical data. The title compounds 17a–i were evaluated for their anti-inflammatory activity. Compounds 17b and 17c exhibited potent anti-inflammatory activity as that of standard drug.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5f77ff8e267826cbec10f3218f4f4abf https://doi.org/10.1002/jhet.2888 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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