The effect of roller head pump on platelet deterioration during the simulated extracorporeal circulation
| Autor: | Yukinori Kozuma, Tatsuya Furugaki, Bryan J. Mathis, Hiroaki Sakamoto, Toru Tsukada, Tomomi Nakajima, Yasuyuki Suzuki, Yuji Hiramatsu, Osamu Shigeta |
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| Rok vydání: | 2020 |
| Předmět: |
animal structures
P-selectin 0206 medical engineering Extracorporeal circulation Biomedical Engineering Medicine (miscellaneous) 02 engineering and technology Phosphatidylserine 030204 cardiovascular system & hematology medicine.disease 020601 biomedical engineering Hemolysis Extracorporeal Biomaterials Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Coagulation medicine Platelet Microparticle Cardiology and Cardiovascular Medicine |
| Zdroj: | Journal of Artificial Organs. 24:22-26 |
| ISSN: | 1619-0904 1434-7229 |
| DOI: | 10.1007/s10047-020-01192-x |
| Popis: | Roller pumping results in hemolysis and adverse effects on coagulation, but there are few reports on the influence of roller heads on platelets. Here, we evaluate the interaction between roller pumping and platelet function using a simulated extracorporeal circuit incorporating a vinyl chloride tube and roller head pump with 30 min recirculation. Platelet aggregation, platelet count, microparticle, P-selectin, Phosphatidylserine (PS) exposure and Ricinus Communis Agglutinin 1 (RCA-1) were measured before, 5, 10, 20, and 30 min after the recirculation using 100 ml of fresh human blood that had obtained from healthy volunteers (n = 9). Platelet aggregation and platelet count gradually decreased but microparticles significantly increased after the recirculation (P |
| Databáze: | OpenAIRE |
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