Iodine–NH4OAc mediated regioselective synthesis of 2-aroyl-3-arylimidazo[1,2-a]pyridines from 1,3-diaryl-prop-2-en-1-ones

Autor:	Parthasarathi Das, Annah Gupta, Kamal K. Kapoor, Deepika Singh, Dilpreet Kour, Rajnikant, Vivek K. Gupta
Rok vydání:	2018
Předmět:	Flexibility (engineering) 010405 organic chemistry Chemistry Organic Chemistry Substitution (logic) Regioselectivity Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences
Zdroj:	Organic & Biomolecular Chemistry. 16:1330-1336
ISSN:	1477-0539 1477-0520
DOI:	10.1039/c7ob02750h
Popis:	The present protocol describes an efficient, metal-free regioselective synthesis of 2-aroyl-3-arylimidazo[1,2-a]pyridines from 1,3-diaryl-prop-2-en-1-ones and 2-aminopyridine. The iodine–NH4OAc promoted reaction offers a novel route in the synthesis of 2-aroyl-3-arylimidazo[1,2-a]pyridines. This protocol offers significant flexibility in accessing medicinally important 2-aroyl-3-arylimidazo[1,2-a]pyridines with various substitution patterns.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5f70502c5ef3671f649d8b26fbcd74a9 https://doi.org/10.1039/c7ob02750h Zobrazit plný text záznamu