Abstract 4589: Gamma-tocopherol and mixed tocopherols inhibit AOM-induced colon carcinogenesis that was promoted by moderate but not severe colon inflammation caused by dextran sodium sulfate
| Autor: | Ziying Jiang, Michelle Moreland, Qing Jiang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
medicine.medical_specialty Colorectal cancer business.industry Vitamin E medicine.medical_treatment Colon inflammation gamma-Tocopherol Cancer medicine.disease medicine.disease_cause Proinflammatory cytokine Endocrinology Oncology Internal medicine medicine Cancer research Prostaglandin E2 Carcinogenesis business medicine.drug |
| Zdroj: | Cancer Research. 71:4589-4589 |
| ISSN: | 1538-7445 0008-5472 |
| Popis: | Our previous studies indicate that specific forms of vitamin E such as gamma-tocopherol (gT), the predominant form of vitamin E in US diets, have anti-inflammatory activities by inhibition of proinflammatory eicosanoids including prostaglandin E2 and leucotriene B4. These eicosanoids are known to promote carcinogenesis of different types of cancer including colon cancer. We therefore hypothesize that gT may be an effective anticancer agent against colon cancer. In male BALC mice, we examined potential effect of gT and mixed tocopherols at 1000mg/kg diet on AOM induced colon carcinogenesis which was promoted by 3-cycle DSS (dextrane sodium sulfate, 1.5%, 2.5% and 2%). The results show that two months after carcinogenesis was induced, all the AOM-DSS mice developed tumors located in the distal colon with ∼12 tumors per mouse. Supplementation of gT or gT-rich mixed tocopherols had no significant effects on tumor incidence or tumor size. In a subsequent study, potential effect of gT and gT rich mixed tocopherols were examined in the AOM induced colon cancer that was promoted by moderate colon inflammation caused by one-cycle 1.5% DSS. GT supplementation, although had no effects on total tumor incidence, significantly (P < 0.05) suppressed the incidence of large tumor (>2 mm2) by 60%. Mixed tocopherols showed strong tendency in attenuation of tumor development (50%, P = 0.06). Interestingly, gT but not mixed tocopherols significantly attenuated DSS-induced colon inflammation. These results indicate that gT appears to have anticancer activities via anti-inflammatory mechanisms. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4589. doi:10.1158/1538-7445.AM2011-4589 |
| Databáze: | OpenAIRE |
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