P305 Low ALT is more Common in Patients with IBD than Healthy Controls and is Associated with Active Disease

Autor: A Shafrir, L Katz, A Zinger, R Safadi, I Kaliski
Rok vydání: 2022
Předmět:
Zdroj: Journal of Crohn's and Colitis. 16:i333-i333
ISSN: 1876-4479
1873-9946
DOI: 10.1093/ecco-jcc/jjab232.432
Popis: Background Sarcopenia is underdiagnosed in patients with Inflammatory bowel disease (IBD). Studies have shown that low alanine transaminase (ALT) levels are associated with sarcopenia. We evaluated the association of low ALT levels with the IBD diagnosis and activity. Methods Data of patients from state mandatory health maintenance organization in Israel was collected. Electronic medical records within the past two years included diagnosis, medications, blood and stool tests. Based on ICD9 coding, patients diagnosed with Ulcerative Colitis (UC) or Crohn’s disease (CD) were compared to healthy control group. Patients with ICD9 diagnosis of chronic liver disease, cirrhosis, and age Results Our cohort consisted of, 348,454 patients, of them, 1780 patients with CD and, 916 with UC. Mean ALT was lower among patients with IBD than healthy controls (22.71 vs., 24.04, p-value Of the CD patients, 392 (27.96%) were in the low ALT group. Patients in the low ALT group were younger (38.85 vs., 42.38 p- value Among patients with UC, 204 (30.13%), had low ALT. Patients in the low ALT group were slightly younger (46.92 vs., 49.65 p-value=0.06), less likely to be male, 22.5% vs., 52% p-value In multivariate linear regression models, controlling for age, gender IBD subtype, and smoking status, low ALT was associated with elevated fecal calprotectin and CRP and lower albumin levels (p-value Conclusion Patients with IBD have lower ALT levels than the general population. Among patients with IBD, low ALT is associated with active disease. Further studies are warranted to strengthen the association of low ALT with sarcopenia among patients with IBD.
Databáze: OpenAIRE
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