Studies towards 4-C-alkylation of pyridin-2(1H)-one derivatives

Autor:	Chi Hung Nguyen, Valerie Dolle, Emile Bisagni
Rok vydání:	1997
Předmět:	Chemistry Organic Chemistry Drug Discovery Nucleophilic substitution Order (group theory) Alkylation Biochemistry Medicinal chemistry
Zdroj:	Tetrahedron. 53:12505-12524
ISSN:	0040-4020
Popis:	In order to obtain 4-C-alkylated pyridin-2(1H)-ones, two strategies were studied: nucleophilic substitution of 4-chloro-3-nitropyridinone derivatives which essentially failed and lithiations of 2-methoxy-3-pivaloylaminopyridines which gave the expected products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5f62a7647c44e32aa91b8e52a5d0f450 https://doi.org/10.1016/s0040-4020(97)00771-0 Zobrazit plný text záznamu Full Text from ScienceDirect