Infection with SARS-CoV-2 may alter the half-life of desmopressin (DDAVP) in patients with central diabetes insipidus

Autor:	Ilja Dubinski, Susanne Bechtold-Dalla Pozza, Heinrich Schmidt
Rok vydání:	2022
Předmět:	Endocrinology Endocrinology Diabetes and Metabolism Pediatrics Perinatology and Child Health
Zdroj:	Journal of Pediatric Endocrinology and Metabolism. 35:1544-1546
ISSN:	2191-0251 0334-018X
DOI:	10.1515/jpem-2022-0422
Popis:	We present a 9-year-old boy with diabetes insipidus. The boy is treated with desmopressin (DDAVP) therapy. Under this therapy, the drinking quantity and the laboratory parameters were normal. No nocturia occurred any more. In the context of a clinically mild infection with SARS-CoV-2, the duration of action of DDAVP was significantly prolonged (approximately +50%). The original dosage was then reintroduced and was still sufficient until months later. A possible connection to the infection with SARS-CoV-2 can be suspected. Our case report should make physicians who care for patients with diabetes insipidus aware of such a possible prolongation of the effect of DDAVP. More frequent monitoring may be needed in such patients to assess the risk of symptomatic dilutional hyponatremia.
Databáze:	OpenAIRE
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