Oedema and Increased Vascular Permeability
| Autor: | C. G. Van Arman |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Drug
biology business.industry media_common.quotation_subject food and beverages Vascular permeability Digitalis Pharmacology biology.organism_classification chemistry.chemical_compound Animal model chemistry Vomiting medicine Morphine medicine.symptom Antagonism business media_common medicine.drug Evans Blue |
| Zdroj: | Handbook of Experimental Pharmacology ISBN: 9783642668937 |
| Popis: | No laboratory model using animals can be a perfect duplicate of a human disease. There are always differences of some kind. For a practical result to be achieved, however, such as finding a drug for clinical use, it is not required that the animal model should even remotely resemble the human disease in its superficial aspects. As examples, morphine can be assayed by the curling of a mouse’s tail; digitalis by the vomiting of a pigeon; anesthetics by the membrane resistance of isolated cells; and anti-epileptic drugs by antagonism of electroshock-induced convulsions. Practically, it does not matter whether one measures a side-effect in an assay rather than the desired effect, so long as these vary together in a known manner. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|