Clinical Correlation of Adenoviral Load in the Respiratory Tract Measured by Digital PCR in Immunocompromised Children

Autor: Diego R Hijano, Jose A Ferrolino, Jennifer Hidinger, Jessica N Brazelton, Zhengming Gu, Sri Suganda, Heather L Glasgow, Kim J Allison, Megan Peterson, Ronald H Dallas, Gabriela Maron, Randall T Hayden
Rok vydání: 2023
Předmět:
Zdroj: Open Forum Infectious Diseases. 10
ISSN: 2328-8957
Popis: Immunocompromised patients can have life-threatening adenoviral infection. Viral load in blood and stool is commonly used to guide antiviral therapy. We developed and evaluated a digital polymerase chain reaction assay to quantify human adenovirus in the respiratory tract and showed that higher peak load correlates with disseminated infection, mechanical ventilation, and death.
Databáze: OpenAIRE