A Convenient Procedure for the Preparation of 1-(Diisopropylamino)phospholes − Application to the Synthesis of New 2,2′-Biphosphole Disulfides

Autor:	Maryse Gouygou, Gilbert G. A. Balavoine, Jérôme Hydrio, F. Dallemer, Jean-Claude Daran
Rok vydání:	2002
Předmět:	Molecular model Organic Chemistry Substituent Disulfide bond Ring (chemistry) Combinatorial chemistry chemistry.chemical_compound chemistry Axial chirality Phosphorus atom Phenyl group Organic chemistry Physical and Theoretical Chemistry Chirality (chemistry)
Zdroj:	European Journal of Organic Chemistry. 2002:675-685
ISSN:	1099-0690 1434-193X
Popis:	A convenient one-pot procedure for the preparation of 1-(diisopropylamino)phospholes has been developed. These phospholes have been used in a multistep procedure for synthesizing two new 2,2′-biphosphole disulfide compounds. The structures and stereochemistry of these compounds have been studied by X-ray diffraction analysis and by molecular modeling. The 1-(diisopropylamino) group, used as a bulky substituent on the phosphorus atom in combination with a phenyl group on the ring, proved to be an important factor in the stabilization of the axial chirality of 2,2′-biphosphole framework.
Databáze:	OpenAIRE
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