Individual Radiosensitivity in Lung Cancer Patients Assessed by G0 and Three Color Fluorescence in Situ Hybridization

Autor:	Manfred Schmidt, Anna Ellmann, Barbara Schuster, Theresa Mayo, Rainer Fietkau, Luitpold Distel
Rok vydání:	2018
Předmět:	Pathology medicine.medical_specialty medicine.diagnostic_test Colorectal cancer business.industry medicine.medical_treatment Cancer medicine.disease Radiation therapy Cohort medicine Radiosensitivity Lung cancer business Metaphase Fluorescence in situ hybridization
Zdroj:	OBM Genetics. 3:1-1
ISSN:	2577-5790
DOI:	10.21926/obm.genet.1902082
Popis:	Background: It is known that radiosensitivity is very individual. This can influence the tumor response and side effects in normal tissue after radiotherapy of cancer. Therefore we analyzed the sensitivity of a lung cancer cohort to see if they display a similar radiosensitivity distribution if compared to a healthy individuals and a rectal cancer patients cohort. Methods: Blood samples of 282 individuals were irradiated ex vivo and chromosomes # 1, 2 and 4 were stained by the 3-color fluorescence in situ hybridization. Additionally we analyzed data from 400 partly previous published individuals. Chromosomal aberrations were counted and expressed via breaks per metaphase (B/M). The background chromosomal aberrations were subtracted to obtain solely the radiation induced aberrations. Results: The lung cancer cohort has significantly increased background B/M values (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5f524c90332f56c00f95f1f1bf0f709c https://doi.org/10.21926/obm.genet.1902082 Zobrazit plný text záznamu