Development of nanocarriers of complex composition with the aim of incorporating the therapeutic radionuclide actinium-225 and retaining its daughter isotopes
| Jazyk: | ruština |
|---|---|
| Rok vydání: | 2021 |
| Předmět: | |
| DOI: | 10.18720/spbpu/3/2021/vr/vr21-1879 |
| Popis: | ÐÐ°Ð½Ð½Ð°Ñ ÑабоÑа поÑвÑÑена ÑазÑабоÑке ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ð¹ ÑинÑеза ÑÑеÑиÑеÑÐºÐ¸Ñ SiO2 наноÑаÑÑиÑ, модиÑикаÑии Ð¸Ñ Ð¿Ð¾Ð²ÐµÑÑ Ð½Ð¾ÑÑи меÑаллиÑеÑкими оболоÑками на оÑнове бÑÑокÑида ÑиÑана и ÑеÑÑÐ°Ñ Ð»Ð¾ÑоаÑÑаÑа водоÑода и ÑдеÑÐ¶Ð°Ð½Ð¸Ñ ÑаÑÑиÑами ÑадиоакÑивнÑÑ Ð¸Ð·Ð¾Ñопов акÑиниÑ-225, ÑÑанÑиÑ-221 и виÑмÑÑа-213 в ÑкÑпеÑименÑÐ°Ñ in vitro и in vivo. ÐадаÑи, ÑеÑаемÑе в Ñ Ð¾Ð´Ðµ ÑеализаÑии пÑоекÑа: 1. РазÑабоÑка ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ð¹ ÑинÑеза ÑиликаÑнÑÑ ÑаÑÑÐ¸Ñ Ñ Ð¿Ð¾ÑледоваÑелÑнÑм вклÑÑением в Ð¸Ñ ÑÑÑÑкÑÑÑÑ ÑадиоакÑивного изоÑопа ÐкÑиниÑ-225. 2. ÐодиÑикаÑÐ¸Ñ Ð¿Ð¾Ð»ÑÑенного комплекÑа меÑаллиÑеÑкими оболоÑками на оÑнове бÑÑокÑида ÑиÑана и ÑеÑÑÐ°Ñ Ð»Ð¾ÑоаÑÑаÑ(III) водоÑода. 3. ХаÑакÑеÑизаÑÐ¸Ñ Ð¿Ð¾Ð»ÑÑеннÑÑ Ð½Ð¾ÑиÑелей Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ñизико-Ñ Ð¸Ð¼Ð¸ÑеÑÐºÐ¸Ñ Ð¼ÐµÑодов. 4. ÐолиÑеÑÑÐ²ÐµÐ½Ð½Ð°Ñ Ð¾Ñенка ÑадиологиÑеÑкой акÑивноÑÑи полÑÑеннÑÑ Ð½Ð¾ÑиÑелей ÑадионÑклидов Ñ Ð¸ÑполÑзованием дозимеÑÑиÑеÑкого и аналиÑиÑеÑкого обоÑÑдованиÑ. 5. ÐзÑÑение воздейÑÑÐ²Ð¸Ñ Ð½Ð¾ÑиÑелей на Ñкани оÑганизма в in vitro и in vivo иÑÑледованиÑÑ . РабоÑа пÑоведена на базе Ð ÐЦРХТ им. Ð. Ð. ÐÑанова и СÐÐÐУ им. ÐеÑÑа Ðеликого, где бÑло ÑобÑана болÑÑÐ°Ñ ÑаÑÑÑ ÑакÑиÑеÑкого маÑеÑиала: ÑазÑабоÑка пÑоÑоколов ÑинÑеза вÑÐµÑ Ñипов ноÑиÑелей и адÑоÑбÑии ÑадиоакÑивнÑÑ Ð¸Ð·Ð¾Ñопов. ÐÑли пÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ ÑÐ°Ð´Ð¸Ð¾Ñ Ð¸Ð¼Ð¸ÑеÑкие иÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾ ÑдеÑÐ¶Ð°Ð½Ð¸Ñ ÑадионÑклидов в полоÑÑи ÑаÑÑÐ¸Ñ Ð² in vitro и in vivo ÑкÑпеÑименÑÐ°Ñ . Ð ÑезÑлÑÑаÑе бÑли ÑазÑабоÑÐ°Ð½Ñ Ð½Ð¾ÑиÑели на базе SiO2 наноÑаÑÑиÑ, покÑÑÑÑе ÑиÑановой и золоÑой оболоÑками. ÐÑоведена Ð¿Ð¾Ð»Ð½Ð°Ñ ÑизиÑеÑÐºÐ°Ñ Ð¸ ÑÐ°Ð´Ð¸Ð¾Ñ Ð¸Ð¼Ð¸ÑеÑÐºÐ°Ñ Ñ Ð°ÑакÑеÑиÑÑика обÑазÑов. ÐзÑÑена ÑÑÐµÐ¿ÐµÐ½Ñ ÑдеÑÐ¶Ð°Ð½Ð¸Ñ ÑадионÑклидов и ÑÑÐµÐ¿ÐµÐ½Ñ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑа на живÑе Ñкани оÑганизмов. This work is devoted to the development of technologies for the synthesis of spherical SiO2 nanoparticles, modification of their surface with metal shells based on titanium butoxide and hydrogen tetrachloroaurate, and the retention of radioactive isotopes of actinium-225, france-221 and bismuth-213 by particles in in vitro and in vivo experiments. Tasks to be solved during the project: 1. Development of technologies for the synthesis of silicate particles with the sequential inclusion of the radioactive isotope Actinium-225 into their structure. 2. Modification of the resulting complex with metal shells based on titanium butoxide and hydrogen tetrachloroaurate (III). 3. Characterization of the obtained carriers using physicochemical methods. 4. Quantitative assessment of the radiological activity of the received carriers of radionuclides using dosimetry and analytical equipment. 5. Study of the effect of carriers on body tissues in in vitro and in vivo studies. The work was carried out on the basis of the N.N. A.M. Granov and St. Peter the Great, where most of the factual material was collected: the development of proto-cols for the synthesis of all types of carriers and the adsorption of radioactive isotopes. Radiochemical studies have been carried out on the retention of radionuclides in the particle cavity in in vitro and in vivo experiments. As a result, supports were developed based on SiO2 nanoparticles covered with titanium and gold shells. The complete physical and radiochemical characteristics of the samples have been carried out. The degree of retention of radionuclides and the degree of influence of the complex on the living tissues of organisms have been studied. |
| Databáze: | OpenAIRE |
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