Microwave-Assisted Aqueous Krapcho Decarboxylation

Autor:	Jeremy D. Mason, S. Shaun Murphree
Rok vydání:	2013
Předmět:	Reaction rate chemistry.chemical_classification Hydrolysis chemistry.chemical_compound Aqueous solution Malonate Chemistry Organic Chemistry Krapcho decarboxylation Salt (chemistry) Organic chemistry Lithium sulfate Alkyl
Zdroj:	Synlett. 24:1391-1394
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0033-1338701
Popis:	The Krapcho decarboxylation of alkyl malonate derivatives has been adapted to aqueous microwave conditions. Various salt additives were examined, and both the cation and the anion impacted the facility of the reaction. A strong correlation was found between the pKa of the anion and the reaction rate, suggesting a straightforward base-catalyzed hydrolysis. Lithium sulfate gave the best results, obviating the need for DMSO co-solvent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5f37a70e21d8e229c3f43933d5f9028a https://doi.org/10.1055/s-0033-1338701 Zobrazit plný text záznamu