Improved synthesis of strigol analog GR24 and evaluation of the biological activity of its diastereomers

Autor:	Rob L. P. De Jong, Eddy M. Mangnus, F. Jan Dommerholt, Binne Zwanenburg
Rok vydání:	1992
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Chemistry Stereochemistry Yield (chemistry) Diastereomer Moiety Organic chemistry Organic synthesis Biological activity General Chemistry General Agricultural and Biological Sciences Lactone
Zdroj:	Journal of Agricultural and Food Chemistry. 40:1230-1235
ISSN:	1520-5118 0021-8561
DOI:	10.1021/jf00019a031
Popis:	A high yield preparation procedure for the germination stimulant GR24 (2) is described. Improvements were introduced in the syntheses of the key building blocks 3 and 4. The tricyclic lactone 3 was prepared from indan-1-one in four steps. The major improvement was the introduction of the carboxymethyl function at the α-position of indan-1-one via an ethoxycarbonyl auxiliary group. The furanone moiety 4 was prepared in four steps in an overall yield of 75% using ethyl α-bromopropionate and oxirane as main starting materials []
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5f2c6dbcf59f823c1efb5fb122e60588 https://doi.org/10.1021/jf00019a031 Zobrazit plný text záznamu